Diabetic retinopathy and transcriptional regulation of a small molecular weight G-Protein, Rac1
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چکیده
منابع مشابه
Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1.
Small guanine nucleotide-binding proteins of the Ras and Rho (Rac, Cdc42, and Rho) families have been implicated in cardiac myocyte hypertrophy, and this may involve the extracellular signal-related kinase (ERK), c-Jun N-terminal kinase (JNK), and/or p38 mitogen-activated protein kinase (MAPK) cascades. In other systems, Rac and Cdc42 have been particularly implicated in the activation of JNKs ...
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Hyperglycemia is thought to be the underlying factor in the development of diabetic retinopathy, but the mechanisms involved remain partially understood. Diabetes increases oxidative stress, and reactive oxygen species affect the interactions between a small-molecular- weight G-protein, H-Ras, and several of its effector proteins. The purpose of this study was to examine the regulatory role of ...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2016
ISSN: 0014-4835
DOI: 10.1016/j.exer.2016.04.014